Acetaminophen is an over-the-counter medication used to treat pain and fever. Acetaminophen works on the parts of your brain that receive “pain messages,” but it does not have the anti-inflammatory effects of NSAIDs. Often, however, in cases of chronic pain there is no inflammation at the site of the pain, and thus Acetaminophen may be an appropriate treatment choice. Acetaminophen is a safe medication when used appropriately, but can be very dangerous when used inappropriately. The risk of liver or kidney damage is significant when more than the recommended dose of Acetaminophen is used. If you have known liver disease, acetaminophen should only be consumed under your doctor’s supervision. Acetaminophen is often combined with other pain medications to cause an additive effect.