Nociceptive pain results from tissue damage. Injury to a specific area occurs, which causes intact neurons to report damage to your brain, and pain is experienced. Nociceptive pain can be subdivided into somatic and visceral (gut) pain. Nociceptive pain can be a sharp sensation, although other times it can be dull or aching. You may experience radiation of the pain, especially visceral pain, but it will not be in a direct nerve distribution. For example, gallbladder pain can radiate to the scapula. Nociceptive pain is generally responsive to and first treated with nonsteroidal anti-inflammatory drugs (NSAIDs), followed with opioids
for more severe pain. Conditions associated with inflammation, bone pain, and joint disease are particularly responsive to NSAIDs.